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文献解读

本周二，麻醉一科古晨博士为大家解读文献《Dexmedetomidineenhancesropivacaine-induced

sciaticnerveinjuryindiabeticrats》。

Dexmedetomidineenhancesropivacaine-induced

sciaticnerveinjuryindiabeticrats

Z.Y.Yu,etc.BritishJournalofAnaesthesia，（1）：-

Background:Previousstudiessuggestthatdexmedetomidinehasaprotectiveeffectagainstlocalanaesthetic-inducednerveinjuryinregionalnerveblocks.Whetherthispotentiallyprotectiveeffectexistsinthecontextofdiabetesmellitusisunknown.

Methods:AdiabeticstatewasestablishedinadultmaleSpraguee-Dawleyratswithintraperitonealinjectionofstreptozotocin.Injectionsofropivacaine0.5%,dexmedetomidine20mg/kg(aloneandin